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Major research articles:

 

IL-22-induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus infection.

Zhang Z, Zou J, Shi Z, Zhang B, Etienne-Mesmin L, Wang Y, Shi X, Shao F, Chassaing B, Gewirtz AT.

Science Immunol. 2020;5(52)

Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.

Viennois E, Pujada A, Sung J, Yang C, Gewirtz AT, Chassaing B, Merlin D.

NPJ Biofilms Microbiomes. 2020;6(1):27

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases.

Tran HQ, Ley RE, Gewirtz AT, Chassaing B.

Nat Commun. 2019;10(1):5650

A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection.

Rolhion N, Chassaing B, Nahori MA, de Bodt J, Moura A, Lecuit M, Dussurget O, Bérard M, Marzorati M, Fehlner-Peach H, Littman DR, Gewirtz AT, Van de Wiele T, Cossart P.

Cell Host Microbe. 2019;26(5):691-701.e5

The intestinal microbiota regulates host cholesterol homeostasis.

Le Roy T, Lécuyer E, Chassaing B, Rhimi M, Lhomme M, Boudebbouze S, Ichou F, Haro Barceló J, Huby T, Guerin M, Giral P, Maguin E, Kapel N, Gérard P, Clément K, Lesnik P.

BMC Biol. 2019;17(1):94

Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection.

Shi Z, Zou J, Zhang Z, Zhao X, Noriega J, Zhang B, Zhao C, Ingle H, Bittinger K, Mattei LM, Pruijssers AJ, Plemper RK, Nice TJ, Baldridge MT, Dermody TS, Chassaing B, Gewirtz AT.

Cell. 2019;179(3):644-658.e13

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell. 2018; 175(3):679-694

 

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Chassaing B*, Sommer F*, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW.

Nature. 2018; 560(7719):489-493

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.

Zou J, Chassaing B, Singh V, Pellizzon M, Ricci M, Fythe MD, Kumar MV, and Gewirtz AT.

Cell Host Microbe. 2018; 23(1):41-53 e4

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation.

Chassaing B, Van de Wiele T, De Bodt J, Marzorati M, Gewirtz AT.

Gut. 2017; 66(8):1414-1427

Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans.

Chassaing B, Raja SM, Lewis JD, Srinivasan S, Gewirtz AT.

Cell Mol Gastroenterol Hepatol. 2017; 4(2):205-221

Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis.

Viennois E, Merlin D, Gewirtz AT, Chassaing B.

Cancer Res. 2017; 77(1):27-40

​Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.

Chassaing B*, Singh V*, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell Metab. 2015; 22(6):983-96

Dietary emulsifiers impact the mouse gut microbiota

promoting colitis and metabolic syndrome.

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT.

Nature. 2015; 519(7541):92-6

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT.

Science. 2014; 346(6211):861-5

 

TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.

Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B.

Immunity. 2014; 41(3):478-92

Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.

Chassaing B, Ley RE, Gewirtz AT.

Gastroenterology. 2014; 147(6):1363-77.e17

Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut.

Cullender TC, Chassaing B, Janzon A, Kumar K, Muller CE, Werner JJ, Angenent LT, Bell ME, Hay AG, Peterson DA, Walter J, Vijay-Kumar M, Gewirtz AT, Ley RE.

Cell Host Microbe. 2013; 14(5):571-81

AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition.

Chassaing B, Koren O, Carvalho FA, Ley RE, Gewirtz AT.

Gut. 2014; 63(7):1069-80

 

Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.

Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT.

Cell Host Microbe. 2012; 12(2):139-52

 

Major review:

 

Microbiota and Metabolism -- What's New in 2018.

Bretin A, Gewirtz AT, Chassaing B.

Am J Physiol Endocrinol Metab. 2018; 315(1):E1-E6

Antibacterial weapons: targeted destruction in the microbiota.

Chassaing B and Cascales E.

Trends in Microbiology. 2018; 26(4):329-338

 

First victim, later aggressor: How the intestinal microbiota drives the pro-inflammatory effects of dietary emulsifiers?

Viennois E, and Chassaing B.

Gut Microbes. 2018; Epub ahead of print

 

Microbiota Alterations in Inflammatory Bowel Diseases: From Correlation to Causality.

Chassaing B.

Cell Mol Gastroenterol Hepatol. 2016; 2(4):403-404

When pathogenic bacteria meet the intestinal microbiota.

Rolhion N, Chassaing B.

Philos Trans R Soc Lond B Biol Sci. 2016; 371(1707)

 

The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases.

Chassaing B, Darfeuille-Michaud A.

Gastroenterology. 2011; 140(6):1720-28