Chassaing Lab

Major research articles:

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Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation.

Kordahi MC, Daniel N, Gewirtz AT, Chassaing B. Gut Microbes. 2025 Dec;17(1):2455790. doi: 10.1080/19490976.2025.2455790

 

Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility.

Delaroque C, Rytter H, Bonazzi E, Huillet M, Ellero-Simatos S, Chatonnat E, Hao F, Patterson A, Chassaing B. Nat Commun. 2025 Jul 29;16(1):6954. doi: 10.1038/s41467-025-62397-3.

 

In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier.

Rytter H, Naimi S, Wu G, Lewis J, Duquesnoy M, Vigué L, Tenaillon O, Belda E, Vazquez-Gomez M, Touly N, Arnone D, Hao F, Ley RE, Clément K, Peyrin-Biroulet L, Patterson AD, Gewirtz AT, Chassaing B. Gut. 2025 Apr 7;74(5):761-774. doi: 10.1136/gutjnl-2024-333925.

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Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice.

Chajadine M, Laurans L, Radecke T, Mouttoulingam N, Al-Rifai R, Bacquer E, Delaroque C, Rytter H, Bredon M, Knosp C, Vilar J, Fontaine C, Suffee N, Vandestienne M, Esposito B, Dairou J, Launay JM, Callebert J, Tedgui A, Ait-Oufella H, Sokol H, Chassaing B, Taleb S. Nat Commun. 2024 Jul 29;15(1):6390. doi: 10.1038/s41467-024-50807-x.

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Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity.

Bonazzi E, Bretin A, Vigué L, Hao F, Patterson AD, Gewirtz AT, Chassaing B. Microbiome. 2024 Jan 5;12(1):5. doi: 10.1186/s40168-023-01724-6.

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Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption.

Daniel N, Wu GD, Walters W, Compher C, Ni J, Delaroque C, Albenberg L, Ley RE, Patterson AD, Lewis JD, Gewirtz AT, Chassaing B. Cell Mol Gastroenterol Hepatol. 2024;17(2):315-318. doi: 10.1016/j.jcmgh.2023.11.001.

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Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism.

Daniel N, Gewirtz AT, Chassaing B. Gut. 2023 May;72(5):906-917. doi: 10.1136/gutjnl-2021-326835.

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Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome.

Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD. Gastroenterology. 2022 Mar;162(3):743-756. doi: 10.1053/j.gastro.2021.11.006.

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Direct impact of commonly used dietary emulsifiers on human gut microbiota.

Naimi S, Viennois E, Gewirtz AT, Chassaing B. Microbiome. 2021 Mar 22;9(1):66. doi: 10.1186/s40168-020-00996-6.

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Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases.

Tran HQ, Ley RE, Gewirtz AT, Chassaing B. Nat Commun. 2019 Dec 11;10(1):5650. doi: 10.1038/s41467-019-13538-y.

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Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection.

Shi Z, Zou J, Zhang Z, Zhao X, Noriega J, Zhang B, Zhao C, Ingle H, Bittinger K, Mattei LM, Pruijssers AJ, Plemper RK, Nice TJ, Baldridge MT, Dermody TS, Chassaing B, Gewirtz AT. Cell. 2019 Oct 17;179(3):644-658.e13. doi: 10.1016/j.cell.2019.09.028.

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Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. Cell. 2018 Oct 18;175(3):679-694.e22. doi: 10.1016/j.cell.2018.09.004.

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Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT. Nature. 2015 Mar 5;519(7541):92-6. doi: 10.1038/nature14232.

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Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Science. 2014 Nov 14;346(6211):861-5. doi: 10.1126/science.1256999.

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Major review:

 

Microbiota insights in endometriosis

Parpex G, Nicco C, Chassaing B, Santulli P, Chouzenoux S, Bourdon M, Maignien C, Doridot L, Batteux F, Chapron C, Marcellin L. Microbiome. 2025 Dec 5;13(1):251. doi: 10.1186/s40168-025-02243-2.

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Microbiome in heritage: how maternal microbiome transmission impacts next generation health.

Delaroque C, Chassaing B. Microbiome. 2025 Sep 26;13(1):196. doi: 10.1186/s40168-025-02186-8.

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Diet-pathobiont interplay in health and inflammatory bowel disease.

Rytter H, Sturgeon H, Chassaing B. Trends Microbiol. 2025 Sep;33(9):948-960. doi: 10.1016/j.tim.2025.04.003

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Adherent-invasive Escherichia coli in Crohn's disease: the 25th anniversary.

Barnich N, Arthur JC, Buisson A, Campbell BJ, Carbonnel F, Chassaing B, Coombes BK, Denizot J, Dogan B, Faith J, Kamada N, Longman RS, Martinez-Medina M, O'Brien CL, Sartor RB, Zhang S; AIEC Research Group; Colombel JF, Simpson KW; AIEC Research group. Gut. 2025 Jun 5:gutjnl-2025-335331. doi: 10.1136/gutjnl-2025-335331

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Ultra-processed foods and food additives in gut health and disease.

Whelan K, Bancil AS, Lindsay JO, Chassaing B. Nat Rev Gastroenterol Hepatol. 2024 Jun;21(6):406-427. doi: 10.1038/s41575-024-00893-5.

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Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights.

Srour B, Kordahi MC, Bonazzi E, Deschasaux-Tanguy M, Touvier M, Chassaing B. Lancet Gastroenterol Hepatol. 2022 Dec;7(12):1128-1140. doi: 10.1016/S2468-1253(22)00169-8.