INSERM U1016 -- CNRS UMR8104 -- Université Paris Cité
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Major research articles:
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Chassaing B, Compher C, Bonhomme B, Liu Q, ... , Lewis JD
Gastroenterology. 2021;Online ahead of print.
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Direct impact of commonly used dietary emulsifiers on human gut microbiota.
Naimi S, Viennois E, Gewirtz AT, Chassaing B.
Microbiome. 2021;9(1):66.
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IL-22-induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus infection.
Zhang Z, Zou J, Shi Z, Zhang B, Etienne-Mesmin L, Wang Y, Shi X, Shao F, Chassaing B, Gewirtz AT.
Science Immunology. 2020;5(52)
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Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.
Viennois E, Pujada A, Sung J, Yang C, Gewirtz AT, Chassaing B, Merlin D.
NPJ Biofilms Microbiomes. 2020;6(1):27
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Tran HQ, Ley RE, Gewirtz AT, Chassaing B.
Nat Commun. 2019;10(1):5650
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Rolhion N, Chassaing B, Nahori MA, de Bodt J, Moura A, Lecuit M, Dussurget O, Bérard M, Marzorati M, Fehlner-Peach H, Littman DR, Gewirtz AT, Van de Wiele T, Cossart P.
Cell Host Microbe. 2019;26(5):691-701.e5
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The intestinal microbiota regulates host cholesterol homeostasis.
Le Roy T, Lécuyer E, Chassaing B, Rhimi M, Lhomme M, Boudebbouze S, Ichou F, Haro Barceló J, Huby T, Guerin M, Giral P, Maguin E, Kapel N, Gérard P, Clément K, Lesnik P.
BMC Biol. 2019;17(1):94
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Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection.
Shi Z, Zou J, Zhang Z, Zhao X, Noriega J, Zhang B, Zhao C, Ingle H, Bittinger K, Mattei LM, Pruijssers AJ, Plemper RK, Nice TJ, Baldridge MT, Dermody TS, Chassaing B, Gewirtz AT.
Cell. 2019;179(3):644-658.e13
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Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.
Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.
Cell. 2018; 175(3):679-694
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
Fulde M, Chassaing B*, Sommer F*, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW.
Nature. 2018; 560(7719):489-493
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Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.
Zou J, Chassaing B, Singh V, Pellizzon M, Ricci M, Fythe MD, Kumar MV, and Gewirtz AT.
Cell Host Microbe. 2018; 23(1):41-53 e4
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Chassaing B, Van de Wiele T, De Bodt J, Marzorati M, Gewirtz AT.
Gut. 2017; 66(8):1414-1427
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Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans.
Chassaing B, Raja SM, Lewis JD, Srinivasan S, Gewirtz AT.
Cell Mol Gastroenterol Hepatol. 2017; 4(2):205-221
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Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis.
Viennois E, Merlin D, Gewirtz AT, Chassaing B.
Cancer Res. 2017; 77(1):27-40
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​Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.
Chassaing B*, Singh V*, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.
Cell Metab. 2015; 22(6):983-96
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Dietary emulsifiers impact the mouse gut microbiota
promoting colitis and metabolic syndrome.
Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT.
Nature. 2015; 519(7541):92-6
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Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT.
Science. 2014; 346(6211):861-5
Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B.
Immunity. 2014; 41(3):478-92
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Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.
Chassaing B, Ley RE, Gewirtz AT.
Gastroenterology. 2014; 147(6):1363-77.e17
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Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut.
Cullender TC, Chassaing B, Janzon A, Kumar K, Muller CE, Werner JJ, Angenent LT, Bell ME, Hay AG, Peterson DA, Walter J, Vijay-Kumar M, Gewirtz AT, Ley RE.
Cell Host Microbe. 2013; 14(5):571-81
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AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition.
Chassaing B, Koren O, Carvalho FA, Ley RE, Gewirtz AT.
Gut. 2014; 63(7):1069-80
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.
Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT.
Cell Host Microbe. 2012; 12(2):139-52
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Major review:
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Host/microbiota interactions in health and diseases-Time for mucosal microbiology!
Daniel N, Lecuyer E, Chassaing B.
Mucosal Immunology. 2021;14(5):1006-1016.
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Microbiota and Metabolism -- What's New in 2018.
Bretin A, Gewirtz AT, Chassaing B.
Am J Physiol Endocrinol Metab. 2018; 315(1):E1-E6
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Antibacterial weapons: targeted destruction in the microbiota.
Chassaing B and Cascales E.
Trends in Microbiology. 2018; 26(4):329-338
First victim, later aggressor: How the intestinal microbiota drives the pro-inflammatory effects of dietary emulsifiers?
Viennois E, and Chassaing B.
Gut Microbes. 2018; Epub ahead of print
Microbiota Alterations in Inflammatory Bowel Diseases: From Correlation to Causality.
Chassaing B.
Cell Mol Gastroenterol Hepatol. 2016; 2(4):403-404
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When pathogenic bacteria meet the intestinal microbiota.
Rolhion N, Chassaing B.
Philos Trans R Soc Lond B Biol Sci. 2016; 371(1707)
The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases.
Chassaing B, Darfeuille-Michaud A.
Gastroenterology. 2011; 140(6):1720-28